IN OTHER LANGUAGES

Essential oils: Mechanisms of action as natural fungicides and antitoxigenics | PlusVet Animal Health
Expertos en fitobióticos y salud digestiva
PlusVet Animal Health, feed additives, feed additives, plant extracts, essential oils, phytobiotics, phytochemicals, phytogenics, replace antibiotics growth promoters, natural products, digestive health, poultry, poultry, swine, pigs, ruminants, aquaculture, rabbits
38724
post-template-default,single,single-post,postid-38724,single-format-standard,bridge-core-3.1.2,qi-blocks-1.2.7,qodef-gutenberg--no-touch,qodef-qi--no-touch,qi-addons-for-elementor-1.7.1,qode-page-transition-enabled,ajax_fade,page_not_loaded,qode-page-loading-effect-enabled,,qode-title-hidden,side_area_uncovered_from_content,footer_responsive_adv,hide_top_bar_on_mobile_header,qode-theme-ver-30.1,qode-theme-bridge,qode_header_in_grid,wpb-js-composer js-comp-ver-7.1,vc_responsive,elementor-default,elementor-kit-1,elementor-page elementor-page-38724

Essential oils: Mechanisms of action as natural fungicides and antitoxigenics

molds, antitoxigenic, mycotoxins, fungicide, biofilm, fungistatic, PlusVet Animal Health, feed additives, feed additives, plant extracts, essential oils, phytobiotics, phytochemicals, phytogenics, replace antibiotics growth promoters, natural products, digestive health, poultry, poultry, swine, pigs, ruminants, aquaculture, rabbits

Plants produce essential oils for a multitude of reasons, such as attracting pollinators, becoming unpalatable to certain animals, inhibiting the growth of other plants, and as a part of the defense system against infections. In this framework, essential oils are powerful antimicrobials, and their effectiveness against bacteria and fungi is scientifically proven.

Synthetic fungicides are largely effective but resistances may appear, especially in the treatment of internal fungal infections. Furthermore, chemical fungicides may affect the environment and be toxic for humans and animals. The use of chemicals with minimal or no toxicity is key, especially in the food chain, so essential oils present a safer alternative and are well accepted by producers and consumers, aligning with the current trend of a “greener” livestock production.

Mechanisms of action as fungistatics and fungicides

Essential oils are both fungicide (kill the fungus) at higher concentrations and fungistatic (inhibit the growth of the fungus without killing it) at lower concentrations. They have multiple sites of action in the fungal cell:

  • Cell wall: Essential oils damage the integrity and rigidity of the cell wall
  • Cell membrane: Essential oils alter its fluidity and permeability, inhibit certain enzymes related to its synthesis, promote membrane degradation, facilitate the leakage of vital cellular components, reduce the proton motive force (energy that is generated by the transfer of protons or electrons across the membrane) and damage membrane proteins.
  • Mitochondria: Essential oils disrupt the energy metabolism in the mitochondria, leading to cell death.
  • Efflux pumps: Essential oils inhibit efflux pumps, which are necessary to remove toxic wastes from the cell.

Mechanisms of action against fungal biofilms

Certain fungi, such as Candida albicans, adhere to the host’s internal organs or to the external surfaces, form biofilms and become more resistant to treatment with chemical antifungals.

Essential oils have strong anti-adhesion and anti-biofilm activities at a concentration lower than the one required to inhibit fungal growth. They are effective both in the prevention of biofilm formation and in the destruction of mature biofilms. In some cases, essential oils have been proven more effective than azole antifungals, but their mechanism of action is little known.

Mechanisms of action as antitoxigenics

Some essential oils have been proven to inhibit mycotoxin production, also at lower concentrations than those needed to inhibit mycelial growth. Currently, the antitoxigenic modes of action of essential oils are not well understood, however, it is hypothesized that they work mainly through two mechanisms:

  • Inhibition of fungal growth, which has the inhibition of mycotoxin production as as a side effect. 
  • Specific inhibition of mycotoxin biosynthetic pathways, not related to fungal growth. 

Do not miss any of our articles!

Subscribe to our monthly newsletter

Would you like further information?

We are at your service!
Copyright© 2022 PlusVet Animal Health

Certain health statements may not be applicable in your region.